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期刊论文 33

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Regional wind power forecasting model with NWP grid data optimized

Zhao WANG, Weisheng WANG, Bo WANG

《能源前沿（英文）》 2017年 第11卷 第2期   页码 175-183 doi: 10.1007/s11708-017-0471-9

摘要： Unlike the traditional fossil energy, wind, as the clean renewable energy, can reduce the emission of the greenhouse gas. To take full advantage of the environmental benefits of wind energy, wind power forecasting has to be studied to overcome the troubles brought by the variable nature of wind. Power forecasting for regional wind farm groups is the problem that many power system operators care about. The high-dimensional feature sets with redundant information are frequently encountered when dealing with this problem. In this paper, two kinds of feature set construction methods are proposed which can achieve the proper feature set either by selecting the subsets or by transforming the original variables with specific combinations. The former method selects the subset according to the criterion of minimal-redundancy-maximal-relevance (mRMR), while the latter does so based on the method of principal component analysis (PCA). A locally weighted learning method is also proposed to utilize the processed feature set to produce the power forecast results. The proposed model is simple and easy to use with parameters optimized automatically. Finally, a case study of 28 wind farms in East China is provided to verify the effectiveness of the proposed method.

关键词： regional wind power forecasting     feature set     minimal-redundancy-maximal-relevance (mRMR)     principal component analysis (PCA)     locally weighted learning model    

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Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

《农业科学与工程前沿（英文）》 2019年 第6卷 第1期   页码 33-41 doi: 10.15302/J-FASE-2018228

摘要：

Female infertility represents a major challenge for improving the production efficiency in the dairy industry. Historically, fertility has declined whereas milk yield has increased tremendously due to intensive genetic selection. evidence reveals about 60% pregnancy loss takes place during the first month following fertilization. Meanwhile, early embryo development is significant for somatic cell nuclear transfer in cattle as a large proportion of cloned embryos fail to develop beyond peri-implantation stage. Oocyte quality is of utmost importance for the early embryo to develop to term for both fertilized and cloned embryos. Epigenetic reprogramming is a key process occurring after fertilization and critical roles of epigenetic modifiers during preimplantation development are now clear. Incomplete epigenetic reprogramming is believed to be a major limitation to cloning efficiency. Treatment of cloned embryos with epigenetic modifying drugs (e.g., Trichostatin A) could greatly improve cloning efficiency in both mice and cattle. Recently, the rapid progress in high-throughput sequencing technologies has enabled detailed deciphering of the molecular mechanisms underlying these events. The robust efficiency of genomic editing tools also presents an alternative approach to the functional annotation of genes critical to early development.

关键词： bovine cloning     embryo development     somatic cell nuclear transfer     X-inactive specific transcript    

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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

null

《医学前沿（英文）》 2013年 第7卷 第4期   页码 401-410 doi: 10.1007/s11684-013-0286-y

摘要：

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens during earlier stages of ESCC or even during precancerous stages. Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve current therapeutics or early intervention of the disease. In this review, we summarize the findings in investigating the molecular alterations and clinical relevance of ESCC.

关键词： esophageal squamous cell carcinoma (ESCC)     early detection     molecular classification     molecular markers    

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

《医学前沿（英文）》   页码 939-956 doi: 10.1007/s11684-023-0987-9

摘要： A small proportion of mononuclear diploid cardiomyocytes (MNDCMs), with regeneration potential, could persist in adult mammalian heart. However, the heterogeneity of MNDCMs and changes during development remains to be illuminated. To this end, 12 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cell RNA sequencing. Three cardiac developmental paths were identified: two switching to cardiomyocytes (CM) maturation with close CM–fibroblast (FB) communications and one maintaining MNDCM status with least CM–FB communications. Proliferative MNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cell communications were identified in the third path. The non-pMNDCMs possessed distinct properties: the lowest mitochondrial metabolisms, the highest glycolysis, and high expression of Myl4 and Tnni1. Single-nucleus RNA sequencing and immunohistochemical staining further proved that the Myl4+Tnni1+ MNDCMs persisted in embryonic and adult hearts. These MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data. In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting the importance of microenvironment contribution to CM fate during maturation. These findings could improve the understanding of MNDCM heterogeneity and cardiac development, thus providing new clues for approaches to effective cardiac regeneration.

关键词： mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing     cardiac regeneration    

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Influence of kinematic redundancy on the singularity-free workspace of parallel kinematic machines

Jens KOTLARSKI, Bodo HEIMANN, Tobias ORTMAIER

《机械工程前沿（英文）》 2012年 第7卷 第2期   页码 120-134 doi: 10.1007/s11465-012-0321-8

摘要：

In this paper the effect of kinematic redundancy in order to reduce the singularity loci of the direct kinematics and to increase the operational, i.e., singularity-free, workspace is demonstrated. The proposed approach consists of additional prismatic actuators allowing one or more base joints to move linearly. As a result, a selective reconfiguration can be performed in order to avoid singular configurations. Exemplarily, kinematically redundant schemes of four structures, the 3RRR, the 3RPR, the 6UPS, and the 6RUS, are considered. The relationship between the redundancy and the operational workspace is studied and several analysis examples demonstrate the effectiveness of the proposed concept. Furthermore, the additional benefit of an increasing number of redundant actuators is discussed.

关键词： parallel robots     kinematic redundancy     singularity avoidance     operational workspace    

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The relevance of James Lovelock’s research and philosophy to environmental science and academia

《环境科学与工程前沿（英文）》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1639-7

摘要： James E. Lovelock, famed for his Gaia hypothesis, which views the Earth as a living integrated and interconnected self-regulating system whose equilibrium comes about from complex energy-based interactions and feedback loops, ultimately sustaining life, passed away at the end of July, 2022 at the age of 103. Not only are the adaptive mechanisms of Gaia central to the conversation of environmental homeostasis, they lie at the heart of climate change and global warming. Lovelock is also remembered as the co-inventor of the electron capture detector that eventually allowed for the sensitive detection of chlorofluorocarbons and pesticides. Finally, Lovelock’s free-spirited nature and research independence allow academia to rethink current research’s modus operandi.

关键词： Academic independence     Climate change     Electron capture detector     Environmental equilibrium     Global warming     Homeostasis    

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effective for patients with acute leukemia/myelodysplastic syndrome with unsatisfactory response to minimal

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

《医学前沿（英文）》 2019年 第13卷 第2期   页码 238-249 doi: 10.1007/s11684-017-0599-3

摘要： The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI) ( =24). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Recombinant human IFN-α-2b injections were subcutaneously administered 2–3 times a week for 6 months. Nine (37.5%), 6 (25.0%), and 3 (12.5%) patients became MRD-negative at 1, 2, and>2 months after the salvage IFN-α treatment, respectively. Two-year cumulative incidences of relapse and non-relapse mortality were 35.9% and 8.3%, respectively. Two-year probabilities of event-free survival, disease-free survival, and overall survival were 51.6%, 54.3%, and 68.0%, respectively. Outcomes of patients subjected to salvage IFN-α treatment after DLI were significantly better than those with persistent MRD without IFN-α treatment. Moreover, clinical outcomes were comparable between the salvage DLI and IFN-α treatment groups. Thus, salvage IFN-α treatment may help improve the outcome of patients with unsatisfactory responses to MRD-directed DLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell transplantation.

关键词： interferon-α     hematopoietic stem cell transplantation     minimal residual disease     donor lymphocyte infusion    

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Erratum to: Efficient keyword search over graph-structured data based on minimal covered Erratum

Asieh Ghanbarpour, Abbas Niknafs, Hassan Naderi,naderi@iust.ac.ir

《信息与电子工程前沿（英文）》 2020年 第21卷 第6期   页码 809-962 doi: 10.1631/FITEE.18e0133

摘要： Unfortunately the second author’s name has been misspelt. It should be read: Abbas NIKNAFS.
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Minimal residual disease in solid tumors: an overview

《医学前沿（英文）》 2023年 第17卷 第4期   页码 649-674 doi: 10.1007/s11684-023-1018-6

摘要： Minimal residual disease (MRD) is termed as the small numbers of remnant tumor cells in a subset of patients with tumors. Liquid biopsy is increasingly used for the detection of MRD, illustrating the potential of MRD detection to provide more accurate management for cancer patients. As new techniques and algorithms have enhanced the performance of MRD detection, the approach is becoming more widely and routinely used to predict the prognosis and monitor the relapse of cancer patients. In fact, MRD detection has been shown to achieve better performance than imaging methods. On this basis, rigorous investigation of MRD detection as an integral method for guiding clinical treatment has made important advances. This review summarizes the development of MRD biomarkers, techniques, and strategies for the detection of cancer, and emphasizes the application of MRD detection in solid tumors, particularly for the guidance of clinical treatment.

关键词： MRD     solid tumor     CTC     ctDNA    

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Reliability analysis of the control system of large-scale vertical mixing equipment

YANG Mingjin, LI Xiwen, LI Shaoping, YANG Shuzi

《机械工程前沿（英文）》 2008年 第3卷 第2期   页码 133-138 doi: 10.1007/s11465-008-0037-y

摘要： The control system of vertical mixing equipment is a concentrate distributed monitoring system (CDMS). A reliability analysis model was built and its analysis was conducted based on reliability modeling theories such as the graph theory, Markov process, and redundancy theory. Analysis and operational results show that the control system can meet all technical requirements for high energy composite solid propellant manufacturing. The reliability performance of the control system can be considerably improved by adopting a control strategy combined with the hot spared redundancy of the primary system and the cold spared redundancy of the emergent one. The reliability performance of the control system can be also improved by adopting the redundancy strategy or improving the quality of each component and cable of the system.

关键词： composite     redundancy     monitoring     vertical     technical    

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基于拉索安全评估的普通斜拉桥和矮塔斜拉桥结构冗余度对比研究 Article

Khawaja Ali, Hiroshi Katsuchi, Hitoshi Yamada

《工程（英文）》 2021年 第7卷 第1期   页码 111-123 doi: 10.1016/j.eng.2020.07.021

摘要：

本研究基于斜拉桥和矮塔斜拉桥的拉索安全性评估，为比较斜拉桥和矮塔斜拉桥提供了新的观点。由于二者都使用拉索，人们通常认为这两种类型的桥梁具有相同的结构。但是，国际桥梁设计标准规定了二者各自的拉索安全系数。为了纠正这一误解，本研究通过考虑各种异常因素和破坏因素（如过载、钢索损耗和钢索腐蚀）的影响，对在疲劳和极限状态下的拉索的安全系数进行了比较。本研究的主要目的是解释两种类型桥梁之间的结构差异，并通过采用确定性和非确定性方法来评估其结构冗余。为了实现这一目标，根据日本现行的拉索设计指南，本文建立了两座桥的三维模型。在达到桥梁模型的平衡状态之后，以参数化方式对拉索的不同安全系数进行了静态分析。最后，采用一阶可靠性方法和蒙特卡洛方法确定了拉索的可靠性指标。分析结果表明，在相同的荷载条件下，斜拉桥和矮塔斜拉桥在不同安全系数下具有不同的结构冗余度。此外，随着拉索的安全系数的增加，其结构上的冗余大大增加。

关键词： 斜拉桥     矮塔斜拉桥     冗余     拉索     安全系数     可靠性分析    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 25-30 doi: 10.1007/s11684-013-0244-8

摘要：

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.

关键词： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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测量与信息技术

张国雄

《中国工程科学》 2000年 第2卷 第3期   页码 62-66

摘要：

测量是获取信息的重要手段。科学研究、生产、高科技发展都离不开测量。测量技术发展的重要特点是它与信息技术的融合，这是提高测量精度、在线和动态测量、复杂参数和复杂环境下测量、智能测量的需要。这一融合贯穿始终，它包括信号调制与解调、采样与重构、信号融合、数据压缩、滤波、信号变换、时间序列分析、谱分析、数据拟合与建模、模式识别、神经网络、仿真与虚拟、误差分离、误差补偿、冗余技术、决策与智能技术等，它们互相支持。文章通过三坐标测量机误差补偿、圆度和轴系误差测量，以及大型工程的柔性坐标测量系统，介绍其在提高测量精度、优化、自标定、丢失信息自恢复、系统重组等方面的作用及其关键技术。

关键词： 测量     信息技术     误差补偿     建模     冗余技术     误差分离    

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Phenolic rigid organic filler/isotactic polypropylene composites. II. Tensile properties

QI Dongming, SHAO Jianzhong, WU Minghua, NITTA Kohhei

《化学科学与工程前沿（英文）》 2008年 第2卷 第4期   页码 396-401 doi: 10.1007/s11705-008-0077-1

摘要： A novel phenolic rigid organic filler (KT) was used to modify isotactic polypropylene (iPP). The influence of KT particles on the tensile properties of PP/KT microcomposites was studied by uniaxial tensile test and the morphological structures of the stretched specimens were observed by scanning electron microscopy (SEM) and polarized optical microscopy (POM). We found that the Young’s modulus of PP/KT specimens increased with filler content, while the yield and break of the specimens are related to the filler particles size. The yield stress, the breaking stress and the ultimate elongation of PP/KT specimens were close to those of unfilled iPP specimens when the maximal filler particles size is less than a critical value, which is 7 ?m at a crosshead speed of 10 mm/min and 3 ?m at 200 mm/min, close to that of glass bead but far more than those of other rigid inorganic filler particles. The interfacial interaction was further estimated from yield stress, indicating that KT particles have a moderate interfacial interaction with iPP matrix. Thus, the incorporation of small KT particles can reinforce iPP matrix and simultaneously cause few detrimental effects on the other excellent tensile properties of iPP matrix, due to their organic nature, higher specific area, solid true-spherical shape and the homogenous dispersion of the ROF particles in microcomposites.

关键词： maximal     uniaxial tensile     unfilled     excellent tensile     influence    

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Novel drive mechanism for in-tube micro robots

CHEN Yangzhi, XING Guangquan, PENG Xuefei, LIU Wenguang, YAO Huaping

《机械工程前沿（英文）》 2007年 第2卷 第1期   页码 94-98 doi: 10.1007/s11465-007-0016-8

摘要： The volume of an in-tube micro robot is small and its interior space is very limited. However, conventional transmission methods are unfit to drive in-tube micro robots. A novel micro drive mechanism called the micro-elastic-meshing-wheel is presented in this paper. It can be used for transmitting power and locomotion between two shafts, which are upright and cross in a micro space. The mechanical model of the novel drive mechanism is built, and the maximal transmission force is deduced. Then, sufficient experiments are carried out to test maximal transmission force produced by the novel drive mechanism. The calculation and experiment results show that the novel drive mechanism can transmit sufficient power to in-tube micro robots.

关键词： limited     conventional transmission     maximal transmission     upright     calculation    

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标题 作者 时间 类型 操作

Regional wind power forecasting model with NWP grid data optimized

Zhao WANG, Weisheng WANG, Bo WANG

期刊论文

Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

期刊论文

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

null

期刊论文

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

期刊论文

Influence of kinematic redundancy on the singularity-free workspace of parallel kinematic machines

Jens KOTLARSKI, Bodo HEIMANN, Tobias ORTMAIER

期刊论文

The relevance of James Lovelock’s research and philosophy to environmental science and academia

期刊论文

effective for patients with acute leukemia/myelodysplastic syndrome with unsatisfactory response to minimal

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

期刊论文

Erratum to: Efficient keyword search over graph-structured data based on minimal covered

Asieh Ghanbarpour, Abbas Niknafs, Hassan Naderi,naderi@iust.ac.ir

期刊论文

Minimal residual disease in solid tumors: an overview

期刊论文

Reliability analysis of the control system of large-scale vertical mixing equipment

YANG Mingjin, LI Xiwen, LI Shaoping, YANG Shuzi

期刊论文

基于拉索安全评估的普通斜拉桥和矮塔斜拉桥结构冗余度对比研究

Khawaja Ali, Hiroshi Katsuchi, Hitoshi Yamada

期刊论文

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

期刊论文

测量与信息技术

张国雄

期刊论文

Phenolic rigid organic filler/isotactic polypropylene composites. II. Tensile properties

QI Dongming, SHAO Jianzhong, WU Minghua, NITTA Kohhei

期刊论文

Novel drive mechanism for in-tube micro robots

CHEN Yangzhi, XING Guangquan, PENG Xuefei, LIU Wenguang, YAO Huaping

期刊论文